Senior Scientist/Scientist Molecular Genomics

Cabaletta Bio
US - Pennsylvania - Phila
May 24, 2024

Senior Scientist/Scientist, Molecular Genomics

Philadelphia, PA

About the Position

We are seeking a talented and experienced Senior Scientist/Scientist with expertise in Molecular Genomics, specifically focused on Cell Therapy, to join our innovative Analytical Development team.
Reporting to Principal Scientist, the successful candidate will play a key role in advancing our understanding of genetic mechanisms underlying CAART and CARTA cell therapies and will contribute to the development of novel genomic approaches to improve the manufacturing process which may lead to optimization of treatment efficacy and safety.
This position requires a strong background in molecular biology, genomics, and cell therapy, as well as proficiency in next-generation sequencing (NGS) technologies and data analysis.
The Senior Scientist/Scientist will collaborate closely with interdisciplinary teams to drive cutting-edge research projects aimed at translating genomic insights into transformative cell-based therapeutic strategies.

Join us in our mission to advance the field of cell therapy to cure autoimmune diseases through innovative molecular genomics approaches.
We offer a stimulating work environment, competitive compensation, and opportunities for professional growth and career development.
If you are passionate about leveraging genomics to enhance the efficacy and safety of cell-based therapies, we invite you to apply and contribute your expertise to our dynamic team.

Responsibilities Include
• Lead and oversee research projects at the intersection of molecular genomics and cell therapy, from conceptualization to execution and data analysis.
• Design and optimize molecular biology protocols tailored to the specific requirements of cell therapy applications, including but not limited to gene editing, gene expression analysis, and single-cell genomics.
• Implement state-of-the-art NGS technologies and bioinformatics tools to characterize genomic profiles and assess genetic stability for CABA-201 product.
• Analyze genomic data sets to identify gene expression profiles, genetic variants, and signaling pathways in CABA-201 product associated with therapeutic outcomes and potential adverse effects.
• Collaborate closely with cell biologists, immunologists, bioinformaticians, and clinical researchers to integrate genomic insights into the development and optimization of cell therapy products.
• Generate and communicate research findings through presentations, scientific publications, and contributions to regulatory documents.
• Stay abreast of emerging technologies, methodologies, and scientific literature in the fields of molecular genomics and cell therapy, and apply this knowledge to advance research objectives.
• Provide technical guidance, mentorship, and training to junior scientists and research associates within the team.

Required Qualifications
• MS with degree in Molecular Biology, Genomics, Cell Biology, Immunology and 3-5 years of relevant experience or Ph.D.
or equivalent degree in Molecular Biology, Genomics, Cell Biology, Immunology, or a related discipline with 2-4 years of experience.
• 3-5 years of hands-on experience in molecular biology techniques relevant to cell therapy, such as gene editing (e.g., CRISPR/Cas9), lentiviral transduction, and cell culture.
• Proficiency in next-generation sequencing (NGS) technologies and associated data analysis tools, including variant calling, RNA sequencing, and single-cell genomics.
• Demonstrated expertise in the application of genomic approaches to study cell therapy products, assess genomic integrity, and evaluate therapeutic efficacy.
• Strong analytical skills with the ability to interpret complex genomic data sets and derive actionable insights to inform therapeutic development.
• Excellent communication and collaboration skills, with the ability to work effectively in interdisciplinary teams and present scientific findings to diverse audiences.
• Track record of scientific publications in peer-reviewed journals showcasing contributions to the field of molecular genomics or cell therapy.
• Prior experience in project leadership, including experimental design, project planning, and supervision of research activities.
• Knowledge of regulatory requirements and quality standards relevant to cell therapy research and development is advantageous.

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