Question 2 / 8:  Both retrospective cohort and case-control study designs are classified as observational studies. What is the essential difference between the design of a retrospective cohort study and the design of a case-control study?
Answer: 
In cohort studies, including retrospective cohort studies, the groups are assembled based of their exposure status. In a case-control study, the groups are assembled based on the disease status.
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Epidemiology & Biostatistics Case-control Studies

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Attribution:  Janet, E.A. Forrester, Kwan Ho Kenneth Chui, Steven Cohen, Michael D. Kneeland, Alice Tang, David Tybor. Epidemiology and Biostatistics 2010. (Tufts University OpenCourseWare), http://ocw.tufts.edu/Course/65/ (Accessed 3 May, 2014). License: Creative Commons BY-NC-SA
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