Common Antiviral Drugs | ||
---|---|---|
Mechanism of Action | Drug | Clinical Uses |
Nucleoside analog inhibition of nucleic acid synthesis | Acyclovir | Herpes virus infections |
Azidothymidine/zidovudine (AZT) | HIV infections | |
Ribavirin | Hepatitis C virus and respiratory syncytial virus infections | |
Vidarabine | Herpes virus infections | |
Sofosbuvir | Hepatitis C virus infections | |
Non-nucleoside noncompetitive inhibition | Etravirine | HIV infections |
Inhibit escape of virus from endosomes | Amantadine, rimantadine | Infections with influenza virus |
Inhibit neuraminadase | Olsetamivir, zanamivir, peramivir | Infections with influenza virus |
Inhibit viral uncoating | Pleconaril | Serious enterovirus infections |
Inhibition of protease | Ritonavir | HIV infections |
Simeprevir | Hepatitis C virus infections | |
Inhibition of integrase | Raltegravir | HIV infections |
Inhibition of membrane fusion | Enfuviritide | HIV infections |
- Why is HIV difficult to treat with antivirals?
To learn more about the various classes of antiretroviral drugs used in the ART of HIV infection, explore each of the drugs in the HIV drug classes provided by US Department of Health and Human Services at this website.
Key concepts and summary
- Because fungi, protozoans, and helminths are eukaryotic organisms like human cells, it is more challenging to develop antimicrobial drugs that specifically target them. Similarly, it is hard to target viruses because human viruses replicate inside of human cells.
- Antifungal drugs interfere with ergosterol synthesis, bind to ergosterol to disrupt fungal cell membrane integrity, or target cell wall-specific components or other cellular proteins.
- Antiprotozoan drugs increase cellular levels of reactive oxygen species, interfere with protozoal DNA replication (nuclear versus kDNA, respectively), and disrupt heme detoxification.
- Antihelminthic drugs disrupt helminthic and protozoan microtubule formation; block neuronal transmissions; inhibit anaerobic ATP formation and/or oxidative phosphorylation; induce a calcium influx in tapeworms, leading to spasms and paralysis; and interfere with RNA synthesis in schistosomes.
- Antiviral drugs inhibit viral entry, inhibit viral uncoating, inhibit nucleic acid biosynthesis, prevent viral escape from endosomes in host cells, and prevent viral release from infected cells.
- Because it can easily mutate to become drug resistant, HIV is typically treated with a combination of several antiretroviral drugs , which may include reverse transcriptase inhibitors, protease inhibitors, integrase inhibitors , and drugs that interfere with viral binding and fusion to initiate infection.
Fill in the blank
Antiviral drugs, like Tamiflu and Relenza, that are effective against the influenza virus by preventing viral escape from host cells are called ________.
neuraminidase inhibitors
True/false
Echinocandins, known as “penicillin for fungi,” target β(1→3) glucan in fungal cell walls.
true
Short answer
How does the biology of HIV necessitate the need to treat HIV infections with multiple drugs?
Niclosamide is insoluble and thus is not readily absorbed from the stomach into the bloodstream. How does the insolubility of niclosamide aid its effectiveness as a treatment for tapeworm infection?