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    Why do ions have a difficult time getting through plasma membranes despite their small size?

    Ions are charged, and consequently, they are hydrophilic and cannot associate with the lipid portion of the membrane. Ions must be transported by carrier proteins or ion channels.

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Source:  OpenStax, Cell biology. OpenStax CNX. Jan 04, 2014 Download for free at https://legacy.cnx.org/content/col11570/1.3
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