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    Explain the difference between a proto-oncogene and a tumor suppressor gene.

    A proto-oncogene is the segment of DNA that codes for one of the positive cell-cycle regulators. If that gene becomes mutated to a form that is overactive, it is considered an oncogene. A tumor suppressor gene is a segment of DNA that codes for one of the negative cell-cycle regulators. If that gene becomes mutated to a form that is underactive, the cell cycle will run unchecked.

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Source:  OpenStax, Concepts of biology_biol 101 dacc. OpenStax CNX. Jan 13, 2014 Download for free at http://legacy.cnx.org/content/col11614/1.1
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