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Cell growth

Cell signaling pathways also play a major role in cell division. Cells do not normally divide unless they are stimulated by signals from other cells. The ligands that promote cell growth are called growth factors . Most growth factors bind to cell-surface receptors that are linked to tyrosine kinases. These cell-surface receptors are called receptor tyrosine kinases (RTKs). Activation of RTKs initiates a signaling pathway that includes a G-protein called RAS, which activates the MAP kinase pathway described earlier. The enzyme MAP kinase then stimulates the expression of proteins that interact with other cellular components to initiate cell division.

Career connection

Cancer biologist

Cancer biologists study the molecular origins of cancer with the goal of developing new prevention methods and treatment strategies that will inhibit the growth of tumors without harming the normal cells of the body. As mentioned earlier, signaling pathways control cell growth. These signaling pathways are controlled by signaling proteins, which are, in turn, expressed by genes. Mutations in these genes can result in malfunctioning signaling proteins. This prevents the cell from regulating its cell cycle, triggering unrestricted cell division and cancer. The genes that regulate the signaling proteins are one type of oncogene which is a gene that has the potential to cause cancer. The gene encoding RAS is an oncogene that was originally discovered when mutations in the RAS protein were linked to cancer. Further studies have indicated that 30 percent of cancer cells have a mutation in the RAS gene that leads to uncontrolled growth. If left unchecked, uncontrolled cell division can lead tumor formation and metastasis, the growth of cancer cells in new locations in the body.

Cancer biologists have been able to identify many other oncogenes that contribute to the development of cancer. For example, HER2 is a cell-surface receptor that is present in excessive amounts in 20 percent of human breast cancers. Cancer biologists realized that gene duplication led to HER2 overexpression in 25 percent of breast cancer patients and developed a drug called Herceptin (trastuzumab). Herceptin is a monoclonal antibody that targets HER2 for removal by the immune system. Herceptin therapy helps to control signaling through HER2. The use of Herceptin in combination with chemotherapy has helped to increase the overall survival rate of patients with metastatic breast cancer.

More information on cancer biology research can be found at the National Cancer Institute website (http://www.cancer.gov/cancertopics/understandingcancer/targetedtherapies).

Cell death

When a cell is damaged, superfluous, or potentially dangerous to an organism, a cell can initiate a mechanism to trigger programmed cell death, or apoptosis    . Apoptosis allows a cell to die in a controlled manner that prevents the release of potentially damaging molecules from inside the cell. There are many internal checkpoints that monitor a cell’s health; if abnormalities are observed, a cell can spontaneously initiate the process of apoptosis. However, in some cases, such as a viral infection or uncontrolled cell division due to cancer, the cell’s normal checks and balances fail. External signaling can also initiate apoptosis. For example, most normal animal cells have receptors that interact with the extracellular matrix, a network of glycoproteins that provides structural support for cells in an organism. The binding of cellular receptors to the extracellular matrix initiates a signaling cascade within the cell. However, if the cell moves away from the extracellular matrix, the signaling ceases, and the cell undergoes apoptosis. This system keeps cells from traveling through the body and proliferating out of control, as happens with tumor cells that metastasize.

Questions & Answers

distinguish between anatomy and physiology
Amina Reply
Anatomy is the study of internal structure of an organism while physiology is the study of the function/relationship of the body organs working together as a system in an organism.
adeyeye
distinguish between anatomy and physiology
Erny Reply
regional anatomy is the study of the body regionally
Ismail Reply
what is the meaning of regional anatomy
Aminat Reply
epithelial tissue: it covers the Hollow organs and body cavities
Esomchi Reply
in short way what those epithelial tissue mean
Zainab Reply
in short way what those epithelial tissue mean
Chizoba
What is the function of the skeleton
Lilias Reply
movement
Ogar
Locomotion
Ojo
support
Aishat
and body shape/form
Aishat
what is homeostasis?
Samuel Reply
what's physiology
AminchiSunday Reply
what is physiology
AminchiSunday
physically is the study of the function of the body
Najaatu
that is what I want ask
YAU
u are wright
YAU
pls what are the main treatment of hiccups
YAU
physiology is the study of the function of the body
Najaatu
hiccups happen when something irritates the nerves that course your diaphragm to contract
Najaatu
how did hypothalamus manege to control all activities of the various hormones
malual
what is protein
Abdulsalam
how can I treat pain a patient feels after eating meals
Namuli Reply
how do I treat a three year old baby of skin infection?
Okocha Reply
It depends on the type of infection. Bacterial, fungal, parasitic or viral?
schler
if you can share the sign ad symptoms of the skin infection then u geh the treatment cox they're different sign ad symptoms of skin infection with different treatment
Sa
the sign and symptoms of maleria
Abdulsalam
prostaglandin and fever
Maha Reply
yes
rayyanu
welcome sir
rayyanu
prostaglandin E2 is the final mediator.
Lemlem
prostaglandin E2 is the final mediator of fever.
Lemlem
yes
Agabi
good evening
Jediel
tissue.
Akoi
explain
Chizoba
Hi
Anya
,good evening
Anya
Discuss the differences between taste and flavor, including how other sensory inputs contribute to our  perception of flavor.
John Reply
taste refers to your understanding of the flavor . while flavor one The other hand is refers to sort of just a blend things.
Faith
While taste primarily relies on our taste buds, flavor involves a complex interplay between taste and aroma
Kamara
which drugs can we use for ulcers
Ummi Reply
omeprazole
Kamara
what
Renee
what is this
Renee
is a drug
Kamara
of anti-ulcer
Kamara
Omeprazole Cimetidine / Tagament For the complicated once ulcer - kit
Patrick
what is the function of lymphatic system
Nency Reply
Not really sure
Eli
to drain extracellular fluid all over the body.
asegid
The lymphatic system plays several crucial roles in the human body, functioning as a key component of the immune system and contributing to the maintenance of fluid balance. Its main functions include: 1. Immune Response: The lymphatic system produces and transports lymphocytes, which are a type of
asegid
to transport fluids fats proteins and lymphocytes to the blood stream as lymph
Adama
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Source:  OpenStax, Genetics and evolution. OpenStax CNX. Aug 07, 2014 Download for free at https://legacy.cnx.org/content/col11595/1.2
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