<< Chapter < Page Chapter >> Page >

Rna

Ribonucleic acid, or RNA, is mainly involved in the process of protein synthesis under the direction of DNA. RNA is usually single-stranded and is made of ribonucleotides that are linked by phosphodiester bonds. A ribonucleotide in the RNA chain contains ribose (the pentose sugar), one of the four nitrogenous bases (A, U, G, and C), and the phosphate group.

There are four major types of RNA: messenger RNA (mRNA), ribosomal RNA (rRNA), transfer RNA (tRNA), and microRNA (miRNA). The first, mRNA, carries the message from DNA, which controls all of the cellular activities in a cell. If a cell requires a certain protein to be synthesized, the gene for this product is turned “on” and the messenger RNA is synthesized in the nucleus. The RNA base sequence is complementary to the coding sequence of the DNA from which it has been copied. However, in RNA, the base T is absent and U is present instead. If the DNA strand has a sequence AATTGCGC, the sequence of the complementary RNA is UUAACGCG. In the cytoplasm, the mRNA interacts with ribosomes and other cellular machinery ( [link] ).

An illustration of a ribosome is shown. mRNA sits between the large and small subunits. tRNA molecules bind the ribosome and add amino acids to the growing peptide chain.
A ribosome has two parts: a large subunit and a small subunit. The mRNA sits in between the two subunits. A tRNA molecule recognizes a codon on the mRNA, binds to it by complementary base pairing, and adds the correct amino acid to the growing peptide chain.

The mRNA is read in sets of three bases known as codons. Each codon codes for a single amino acid. In this way, the mRNA is read and the protein product is made. Ribosomal RNA (rRNA) is a major constituent of ribosomes on which the mRNA binds. The rRNA ensures the proper alignment of the mRNA and the ribosomes; the rRNA of the ribosome also has an enzymatic activity (peptidyl transferase) and catalyzes the formation of the peptide bonds between two aligned amino acids. Transfer RNA (tRNA) is one of the smallest of the four types of RNA, usually 70–90 nucleotides long. It carries the correct amino acid to the site of protein synthesis. It is the base pairing between the tRNA and mRNA that allows for the correct amino acid to be inserted in the polypeptide chain. microRNAs are the smallest RNA molecules and their role involves the regulation of gene expression by interfering with the expression of certain mRNA messages. [link] summarizes features of DNA and RNA.

Features of DNA and RNA
DNA RNA
Function Carries genetic information Involved in protein synthesis
Location Remains in the nucleus Leaves the nucleus
Structure Double helix Usually single-stranded
Sugar Deoxyribose Ribose
Pyrimidines Cytosine, thymine Cytosine, uracil
Purines Adenine, guanine Adenine, guanine

Even though the RNA is single stranded, most RNA types show extensive intramolecular base pairing between complementary sequences, creating a predictable three-dimensional structure essential for their function.

As you have learned, information flow in an organism takes place from DNA to RNA to protein. DNA dictates the structure of mRNA in a process known as transcription    , and RNA dictates the structure of protein in a process known as translation    . This is known as the Central Dogma of Life, which holds true for all organisms; however, exceptions to the rule occur in connection with viral infections.

To learn more about DNA, explore the Howard Hughes Medical Institute BioInteractive animations on the topic of DNA.

Section summary

Nucleic acids are molecules made up of nucleotides that direct cellular activities such as cell division and protein synthesis. Each nucleotide is made up of a pentose sugar, a nitrogenous base, and a phosphate group. There are two types of nucleic acids: DNA and RNA. DNA carries the genetic blueprint of the cell and is passed on from parents to offspring (in the form of chromosomes). It has a double-helical structure with the two strands running in opposite directions, connected by hydrogen bonds, and complementary to each other. RNA is single-stranded and is made of a pentose sugar (ribose), a nitrogenous base, and a phosphate group. RNA is involved in protein synthesis and its regulation. Messenger RNA (mRNA) is copied from the DNA, is exported from the nucleus to the cytoplasm, and contains information for the construction of proteins. Ribosomal RNA (rRNA) is a part of the ribosomes at the site of protein synthesis, whereas transfer RNA (tRNA) carries the amino acid to the site of protein synthesis. microRNA regulates the use of mRNA for protein synthesis.

Art connections

[link] A mutation occurs, and cytosine is replaced with adenine. What impact do you think this will have on the DNA structure?

[link] Adenine is larger than cytosine and will not be able to base pair properly with the guanine on the opposing strand. This will cause the DNA to bulge. DNA repair enzymes may recognize the bulge and replace the incorrect nucleotide.

Got questions? Get instant answers now!

Questions & Answers

if three forces F1.f2 .f3 act at a point on a Cartesian plane in the daigram .....so if the question says write down the x and y components ..... I really don't understand
Syamthanda Reply
hey , can you please explain oxidation reaction & redox ?
Boitumelo Reply
hey , can you please explain oxidation reaction and redox ?
Boitumelo
for grade 12 or grade 11?
Sibulele
the value of V1 and V2
Tumelo Reply
advantages of electrons in a circuit
Rethabile Reply
we're do you find electromagnetism past papers
Ntombifuthi
what a normal force
Tholulwazi Reply
it is the force or component of the force that the surface exert on an object incontact with it and which acts perpendicular to the surface
Sihle
what is physics?
Petrus Reply
what is the half reaction of Potassium and chlorine
Anna Reply
how to calculate coefficient of static friction
Lisa Reply
how to calculate static friction
Lisa
How to calculate a current
Tumelo
how to calculate the magnitude of horizontal component of the applied force
Mogano
How to calculate force
Monambi
a structure of a thermocouple used to measure inner temperature
Anna Reply
a fixed gas of a mass is held at standard pressure temperature of 15 degrees Celsius .Calculate the temperature of the gas in Celsius if the pressure is changed to 2×10 to the power 4
Amahle Reply
How is energy being used in bonding?
Raymond Reply
what is acceleration
Syamthanda Reply
a rate of change in velocity of an object whith respect to time
Khuthadzo
how can we find the moment of torque of a circular object
Kidist
Acceleration is a rate of change in velocity.
Justice
t =r×f
Khuthadzo
how to calculate tension by substitution
Precious Reply
hi
Shongi
hi
Leago
use fnet method. how many obects are being calculated ?
Khuthadzo
khuthadzo hii
Hulisani
how to calculate acceleration and tension force
Lungile Reply
you use Fnet equals ma , newtoms second law formula
Masego
please help me with vectors in two dimensions
Mulaudzi Reply
how to calculate normal force
Mulaudzi
Got questions? Join the online conversation and get instant answers!
Jobilize.com Reply

Get Jobilize Job Search Mobile App in your pocket Now!

Get it on Google Play Download on the App Store Now




Source:  OpenStax, Biology. OpenStax CNX. Feb 29, 2016 Download for free at http://cnx.org/content/col11448/1.10
Google Play and the Google Play logo are trademarks of Google Inc.

Notification Switch

Would you like to follow the 'Biology' conversation and receive update notifications?

Ask