• Card 7 / 30: A 65 year old man comes to the emergency room with the acute onset of peri-umbilical abdominal pain, nausea, and vomiting. He drinks alcohol regularly. He takes no medications. On exam, he has a low grade temperature but other vital signs are stable. He has tenderness in the mid-abdomen without rebound or guarding. His lab tests are: ALT 58 U/l AST 95 U/l Total bilirubin 1.1 mg/dl Alkaline phosphatase 89 U/l Amylase 1105 U/l Lipase 1404 U/l Which of the following is the most likely pathophysiologic mechanism to explain the condition which is causing this patients pain?
    A) Prolonged hypotension causing ischemia
    B) Cytotoxic damage to peri-portal hepatocytes
    C) Reduced stimulation of intracellular calcium signaling pathways
    D) Inappropriate activation of pancreatic enzymes
    E) Reduced pancreatic enzyme synthesis and secretion

    Answer:
    D) Inappropriate activation of pancreatic enzymes

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Gastrointestinal Pathophysiology Exam 2005

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Attribution:  Laurence Scott Bailen, Tamsin Knox, Paul Abourjaily, Fredric D. Gordon,Marshall Kaplan,Andrew G. Plaut. PPY 222 Gastrointestinal Pathophysiology, Spring 2007. (Tufts University OpenCourseWare), http://ocw.tufts.edu/Course/47 (Accessed 3 May, 2014). License: Creative Commons BY-NC-SA
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