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    Why is it impossible for humans to digest food that contains cellulose?

    The β 1-4 glycosidic linkage in cellulose cannot be broken down by human digestive enzymes. Herbivores such as cows, buffalos, and horses are able to digest grass that is rich in cellulose and use it as a food source because bacteria and protists in their digestive systems, especially in the rumen, secrete the enzyme cellulase. Cellulases can break down cellulose into glucose monomers that can be used as an energy source by the animal.

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Source:  OpenStax, Cellular macromolecules: bis2a modules 3.0 to 3.5. OpenStax CNX. Jun 15, 2015 Download for free at https://legacy.cnx.org/content/col11827/1.1
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