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Learning objectives

  • Explain the role of microbial activity in diseases of the mouth and oral cavity
  • Compare the major characteristics of specific oral diseases and infections

Despite the presence of saliva and the mechanical forces of chewing and eating, some microbes thrive in the mouth. These microbes can cause damage to the teeth and can cause infections that have the potential to spread beyond the mouth and sometimes throughout the body.

Dental caries

Cavities of the teeth, known clinically as dental caries , are microbial lesions that cause damage to the teeth. Over time, the lesion can grow through the outer enamel layer to infect the underlying dentin or even the innermost pulp . If dental caries are not treated, the infection can become an abscess that spreads to the deeper tissues of the teeth , near the roots, or to the bloodstream.

Tooth decay results from the metabolic activity of microbes that live on the teeth. A layer of proteins and carbohydrates forms when clean teeth come into contact with saliva. Microbes are attracted to this food source and form a biofilm called plaque . The most important cariogenic species in these biofilms is Streptococcus mutans . When sucrose , a disaccharide sugar from food, is broken down by bacteria in the mouth, glucose and fructose are produced. The glucose is used to make dextran , which is part of the extracellular matrix of the biofilm. Fructose is fermented, producing organic acids such as lactic acid . These acids dissolve the minerals of the tooth, including enamel , even though it is the hardest material in the body. The acids work even more quickly on exposed dentin ( [link] ). Over time, the plaque biofilm can become thick and eventually calcify. When a heavy plaque deposit becomes hardened in this way, it is called tartar or dental calculus ( [link] ). These substantial plaque biofilms can include a variety of bacterial species, including Streptococcus and Actinomyces species.

A photo of teeth with yellow plaque; label reads: bacterial biofilms (plaque) develop and produce acid which dissolves tooth enamel. This leads to a diagram showing the process. The first step show a black region labeled decay in the enamel; the dentin and pulp are not yet affected. Yellow material on the tooth and near the region of decay is labeled plaque. Next, the decay expands and is labeled abscess; this reaches the dentin layer. Finally, the abscess expands and causes an infected pulp.
Tooth decay occurs in stages. When bacterial biofilms (plaque) develop on teeth, the acids produced gradually dissolve the enamel, followed by the dentin. Eventually, if left untreated, the lesion may reach the pulp and cause an abscess. (credit: modification of work by “BruceBlaus”/Wikimedia Commons)
A) photo of a tooth with a dark spot labeled decay. B) micrograph of a tooth; dark regions have an arrow. C) photo of a tooth with a hole. D) photo of a tooth with a large, bleeding hole
(a) Tartar (dental calculus) is visible at the bases of these teeth. The darker deposits higher on the crowns are staining. (b) This tooth shows only a small amount of visible decay. (c) An X-ray of the same tooth shows that there is a dark area representing more decay inside the tooth. (d) Removal of a portion of the crown reveals the area of damage. (e) All of the cavity must be removed before filling. (credit: modification of work by “DRosenbach”/Wikimedia Commons)

Some tooth decay is visible from the outside, but it is not always possible to see all decay or the extent of the decay. X-ray imaging is used to produce radiographs that can be studied to look for deeper decay and damage to the root or bone ( [link] ). If not detected, the decay can reach the pulp or even spread to the bloodstream. Painful abscesses can develop.

Questions & Answers

I'm interested in biological psychology and cognitive psychology
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physiological Psychology
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Communication is effective because it allows individuals to share ideas, thoughts, and information with others.
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Every time someone flushes a toilet in the apartment building, the person begins to jumb back automatically after hearing the flush, before the water temperature changes. Identify the types of learning, if it is classical conditioning identify the NS, UCS, CS and CR. If it is operant conditioning, identify the type of consequence positive reinforcement, negative reinforcement or punishment
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Wekolamo
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ARC
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Skinner skipped the whole unconscious phenomenon and rather emphasized on classical conditioning
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Source:  OpenStax, Microbiology. OpenStax CNX. Nov 01, 2016 Download for free at http://cnx.org/content/col12087/1.4
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